Onderzoek

De afdeling Endocrinologie kent twee grote onderzoeksprogramma’s, het één op gebied van Diabetes en Stofwisseling, en het ander op gebied van Endocriene tumoren.

Het onderzoek richt zich zowel op aspecten van epidemiologie, etiologie, pathogenese als interventie, en kent zowel basale, als translationele en klinische aspecten. Er bestaan samenwerkingsverbanden met vele basale en klinische groepen, waaronder Celbiologie, Medische Biologie, Genetica, Proteomics, Nucleaire Geneeskunde, Laboratoriumcentrum, Klinische Farmacologie, Heelkunde, Cardiologie. een klein overzicht van actuele projecten (in het Engels):

Program I: Endocrine tumours and dysfunction
Thyroid cancer: diagnosis and treatment

topic:                     Medullary thyroid cancer
researcher :         H.H.G. Verbeek
promotor:             prof. T.P. Links, prof. J.T.M. Plukker, prof. R.M.W. Hofstra
thesis:                    2015

topic:                     Prognostic factors in differentiated thyroid cancer
researcher:          mrs. D. Van Dijk
promotor:             prof. J.T.M.Plukker, prof. T.P.Links
thesis:                    2015
topic:                     Thyroid cancer in children

researcher           mrs. M. Klein Hesselink,
supervisor            prof T.P. Links, dr. W.Tissing, dr. G. Bocca
thesis                     2016

topic                      Longterm effects of treatment in differentiated thyroid cancer
researcher           mrs. E. Klein Hesselink
supervisor            prof. T.P.Links, dr. J.W. Lefrandt
thesis                     2016

2. Pituitary tumors
topic:                     Long-term effects and quality of life after treatment for pituitary adenoma
and Cushing’s disease
researcher:          mrs. M. Sattler (radiotherapist)
promotor:             prof. J.A. Langendijk, prof. B.H.R. Wolffenbuttel
co-promotor:       dr. A.P. van Beek, dr. A.C.M. van den Bergh
thesis:                    2015

topic:                     Cognitive functioning in secondary adrenal insufficiency
researcher:          mrs. J. Werumeus Buning (psychologist)
promotor:             prof. B.H.R. Wolffenbuttel
co-promotor:       dr. A.P. van Beek

thesis:                    2016
3. Neuro-endocrine tumours

topic:                     Disease activity in MEN 1 and VHL
researcher:          mrs. S.van Asselt
promotor:             prof. T.P. Links, prof. E.G.E. de Vries
co-promotor:       dr. A.H. Brouwers
thesis:                    2014

topic:                     The role of chemokines and angiogenesis in the development of metastasases and the
possible treatment in Von Hippel Lindau Tumours
researcher           mrs. R. Kruizinga
promotor:             prof. E.G.E. de Vries, prof. T.P. Links
co-promotor:       dr. A.M.E. Walenkamp,
thesis :                   2014

topic:                     Diagnosis and treatment of catecholamine secreting neuroendocrine tumors
researcher:          mrs. T.E. Osinga
promotor:             prof. T.P. Links, prof. I.P.Kema
co-promotor:       dr. A.N.A van der Horst-Schrivers, dr. M.N. Kerstens

thesis:                    2016
topic                      VHL disease: clinical aspects
researcher           mrs. C.F.M. Frantzen
promoter              prof. T.P. Links
co promotor         dr. A.N.A. van der Horst-Schrivers
thesis                     2017

topic                      Genetic endocrine syndromes
researcher           mrs. K. Eijkelenkamp
promoter              prof. T.P. Links
co promotor         dr. A.N.A. van der Horst-Schrivers
thesis                     2018

Program II: Diabetes / Lipids / Vascular
1. Pathophysiology, genetics and treatment of diabetes and diabetes-related complications
a. The role of endogenous and exogenous AGEs in the development of diabetic complications
b. Genomics and proteomics of diabetic complications
The role of CETP and HDL in (diabetic) cardiovascular disease; HDL function
Thyroid function and cardiovascular risk markers
Etiology and treatment of type 1 diabetes
Genetic predisposition for type 2 diabetes
Gene-environment interaction and epigenetic modifications in the development of type 2 diabetes and its complications
Role of endocrine disruptors in type 2 diabetes and obesity

topic:                     Lipids and lipoproteins in cardiovascular disease
researcher:          P.J.H.W. Kappelle
promotor:             prof. B.H.R. Wolffenbuttel
co-promotor:       dr. R.P.F. Dullaart, dr. G. Dallinga-Thie (AMC/UvA)
thesis:                    2016

topic:                     Epigenetic markers of obesity and diabetes, translation to large cohorts
postdoc:                dr. H.L. Lutgers, dr. J.V. van Vliet-Ostaptchouk
project members: prof. B.H.R. Wolffenbuttel, dr. J.V. van Vliet-Ostaptchouk, prof. M.G. Rots,
prof. H. Snieder, prof S.J. Clark, dr. P.L. Molloy

topic:                     Endocrine Disruptors and Type 2 Diabetes
postdoc:                dr. J. Van Vliet-Ostaptchouk,
PhD-student:        to be selected
project members: prof B.H.R. Wolffenbuttel prof. I. Kema, Dr. AM Andersson, prof. H. Snieder
thesis:                    2018
support:                Diabetes Research Foundation (DFN)

topic:                     Gestational diabetes
researcher:          mrs. S. Koning
promotor:             prof. B.H.R. Wolffenbuttel, prof. P.P. van den Berg
co-promotor:       dr. H.L. Lutgers, dr. K. Hoogenberg
thesis:                    2017

topic:                     Biomarkers in diabetes kidney disease
researcher:          mrs. E. Schutte
promotor:             prof. R.T. Gansevoort, prof. B.H.R. Wolffenbuttel
co-promotor:       dr. H.L. Lutgers, dr. H. Lambers Heerspink
thesis:                    2017

topic:                     The AGE reader and skin autofluorescence in the general population
researcher:           R. van Waateringe
promotor:             prof. B.H.R. Wolffenbuttel
co-promotor:       dr. H.L. Lutgers
thesis:                    2017

The projects on genetics of type 2 diabetes are part of the research carried out in the LifeLines Cohort Study, while some of the studies related to diabetic complications are carried out within the String-of-Pearls initiative.
These research programs are carried out by the Department of Endocrinology (dr. R.P.F. Dullaart, dr. T.P. Links, prof. B.H.R. Wolffenbuttel, dr. J.V. van Vliet-Ostaptchouk) in close collaboration with the Dept.’s of General Internal Medicine and Nephrology: prof. S.J.L. Bakker, prof. A.J. Smit, prof. R.O.B. Gans, Department of Internal Medicine, and mrs. dr. G. M. Dallinga-Thie, Department of Vascular Medicine, UVA, with prof. H.J.G. Bilo and dr. N. Kleefstra, Diabetes Centre, Isala Clinics, Zwolle.

L.U.: Oct 2, 2015

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