This week, researchers from our department published a paper in the journal Diabetologia, on the measurement of skin autofluorescence to estimate the risk of developing type 2 diabetes, cardiovascular disease and mortality. The abstract of the paper is as follows:
Earlier studies have shown that skin autofluorescence measured with an AGE reader estimates the accumulation of AGEs in the skin, which increases with ageing and is associated with the metabolic syndrome and type 2 diabetes. In the present study, we examined whether the measurement of skin autofluorescence can predict 4 year risk of incident type 2 diabetes, cardiovascular disease (CVD) and mortality in the general population.
For this prospective analysis, we included 72,880 participants of the Dutch Lifelines Cohort Study, who underwent baseline investigations between 2007 and 2013, had validated baseline skin autofluorescence values available and were not known to have diabetes or CVD. Individuals were diagnosed with incident type 2 diabetes by self-report or by a fasting blood glucose ≥7.0 mmol/l or HbA1c ≥48 mmol/mol (≥6.5%) at follow-up. Participants were diagnosed as having incident CVD (myocardial infarction, coronary interventions, cerebrovascular accident, transient ischaemic attack, intermittent claudication or vascular surgery) by self-report. Mortality was ascertained using the Municipal Personal Records Database.
After a median follow-up of 4 years (range 0.5–10 years), 1056 participants (1.4%) had developed type 2 diabetes, 1258 individuals (1.7%) were diagnosed with CVD, while 928 (1.3%) had died. Baseline skin autofluorescence was elevated in participants with incident type 2 diabetes and/or CVD and in those who had died (all p < 0.001), compared with individuals who survived and remained free of the two diseases. Skin autofluorescence predicted the development of type 2 diabetes, CVD and mortality, independent of several traditional risk factors, such as the metabolic syndrome, glucose and HbA1c.
The non-invasive skin autofluorescence measurement is of clinical value for screening for future risk of type 2 diabetes, CVD and mortality, independent of glycaemic measures and the metabolic syndrome.
The full paper can be found online on the Diabetologia website:
HERE you can find a PowerPoint presentation explaining the concept of measuring skin autofluorescence and the results of the paper in more detail.
You may also find useful information on the website of the manufacturer of the AGe-reader:
Publieke informatie over dit onderzoek vindt u o.a. op:
Gestational diabetes mellitus: diagnosis and outcome.
Need for a revision of the Dutch perspective?
PhD ceremony: S.H. Koning, MSc
When: November 27, 2017
Promotors: prof. dr. B.H.R. (Bruce) Wolffenbuttel, P.P. van den Berg
Where: Academy building RUG, open to the public
Faculty: Medical Sciences / UMCG
Untreated gestational diabetes mellitus (GDM) is associated with an increased risk of complications for both mother and child. Many of these complications can be reduced by early diagnosis and treatment of GDM. However, worldwide there is a lack of agreement on the best way to diagnose and treat GDM.
In the Netherlands, the Dutch Society of Obstetrics and Gynaecology guideline “Diabetes and Pregnancy” for the screening and treatment of GDM was implemented in 2010. The diagnostic thresholds are based on the old WHO consensus originating from 1999 and have until now not been updated to the newest (more stringent) criteria, implemented in 2013. These new criteria have been adopted by many expert committees. However, evidence that applying the stricter criteria for GDM improves pregnancy outcomes is limited.
The research described in this thesis aimed to evaluate the current Dutch national guideline of GDM i.e. what is the outcome of GDM pregnancies using this guideline? And what are consequences when the current diagnostic criteria of GDM are to be revised?
In this thesis we have shown that the currently used national guideline for screening and treatment of GDM is successful in reducing the risk of short-term adverse outcomes, but not in reducing the likelihood of having a large-for-gestational-age neonate. We have also shown that the long-term care for GDM is far from optimal and requires further improvement. In order to further optimize GDM care and pregnancy outcomes we advise the use of more stringent blood glucose criteria for GDM diagnosis.
Background: Early diagnosis and treatment of high blood pressure (BP) and cholesterol is important to reduce cardiovascular risk. We compared BP and LDL-cholesterol (LDL-C) as well as the quality of treatment between obese subjects and normal weight and overweight individuals.
Methods: 87,648 participants of the Lifelines study were categorised according to obesity (normal weight/ overweight/obesity) and age. Mean systolic BP and LDL-C were calculated depending on treatment, BMI, age and sex.
Results: In all age groups, except those aged 70-80 years, women had a significantly lower BP than men. Use of BP-lowering medication did not result in BP levels comparable with non-users, except in those aged 70-80 years. Despite medication, the BP was insufficiently controlled in 20-50% of participants. BP was significantly higher in obese vs. normal weight and overweight individuals of all ages, but most apparently in men younger than 50 years. Mean LDL-C varied between 2.5- .0 mmol/l. Despite higher statin use, obese participants had a higher LDL-C than those with a normal weight. Statins abolished the age-dependent LDL-C increase. Many participants did not achieve target LDL-C < 2.5 mmol/l. A small percentage of individuals treated with BP-lowering drugs were also using statins (overall 32% in men, 17% in women).
Conclusion: Obese individuals, especially men younger than 50, have a higher BP and LDL-C compared with those with overweight and a normal weight. Use of BP-lowering drugs did not revert the BP back to levels normal for the specific age and BMI group, whereas statins abolished the age-related increase in LDL-C. These data suggest that more attention is needed for active screening and treatment of cardiovascular risk factors.
Read the full article at: http://www.njmonline.nl/getpdf.php?id=1911
Introduction and aim: Insight into the total economic burden of diabetes mellitus (DM) is essential for decision makers and payers. Currently available estimates for the Netherlands only include part of the total burden or are no longer up-to-date. Therefore, this study aimed to determine the current total economic burden of DM and its complications in the Netherlands, by including all the relevant cost components.
Methods: The study combined a systematic literature review to identify all relevant published information and a targeted review to identify relevant information in the grey literature. The identified evidence was then combined to estimate the current total economic burden.
Results: In 2016, there were an estimated 1.1 million DM patients in the Netherlands, of whom approximately 10% had type 1 and 90% had type 2 DM. The estimated current total economic burden of DM was € 6.8 billion in 2016. Healthcare costs (excluding costs of complications) were € 1.6 billion, direct costs of complications were € 1.3 billion and indirect costs due to productivity losses, welfare payments and complications were € 4.0 billion.
Conclusion: DM and its complications pose a substantial economic burden to the Netherlands, which is expected to rise due to changing demographics and lifestyle. Indirect costs, such as welfare payments, accounted for a large portion of the current total economic burden of DM, while these cost components are often not included in cost estimations. Publicly available data for key cost drivers such as complications were scarce.
Read the full article at: http://www.njmonline.nl/getpdf.php?id=1883
Epidemiology of metabolic health
Lifestyle determinants and health-related quality of life
PhD ceremony: S.N. Slagter
When: January 11, 2017
Promotor: prof. dr. B.H.R. (Bruce) Wolffenbuttel
Where: Academy building RUG, open to the public.
Faculty: Medical Sciences / UMCG
Overweight and obesity often lead to the development of a disturbed glucose metabolism, increased blood pressure and a disturbed fat profile (too low values of the “good” HDL-cholesterol and high triglycerides values). This combination of metabolic complications is called the metabolic syndrome. It is associated with an increased risk of type 2 diabetes and cardiovascular diseases. Approximately one in four Europeans have the metabolic syndrome. Even though it is usually caused by obesity, a sub-group of obese people seem to be less susceptible to the metabolic health risks. They have an equally healthy metabolism as lean people. In the literature, this is referred to as metabolically healthy obese.
In ten large population studies from seven different European countries the occurrence of the metabolic syndrome and metabolically healthy obesity has been estimated. The metabolic syndrome is common in Europe and the Netherlands. However, in the Dutch LifeLines study still nearly 1 out of 4 obese women and 1 out of 10 obese men are metabolically healthy (depending on their age). From studies with LifeLines data only, it seems that smoking-, drinking-, eating- and exercise behaviours of these people is important. The level of tobacco use and drinking more than one alcoholic beverage per day was already related to the development of the metabolic syndrome. However, a ‘healthy’ dietary pattern and intensive vigorous physical activity increased in obese people the chance of metabolically healthy obesity. Actively changing lifestyle factors will reduce the number of people developing the metabolic syndrome, and consequently will reduce the incidence of type 2 diabetes and cardiovascular diseases. However, even before these more serious chronic conditions occur, obese subjects (without metabolic complications) had an impaired quality of life. Therefore, in the treatment of obesity it is advisable to take into account aspects relating to the quality of life.
Erfelijke stofwisselingsziekten is een groep aangeboren aandoeningen waarbij er sprake is van een defect in een enzym, cofactor of transporter. Hierdoor ontstaat een stoornis in het koolhydraat-, vet- of eiwitmetabolisme, of in de synthese of afbraak van complexe moleculen. Er zijn momenteel ruim 800 erfelijke metabole ziekten beschreven, waarvan de meeste zeldzaam tot uiterst zeldzaam zijn. Er wordt echter geschat dat ten minste 1 op de 2500 levendgeborenen een stofwisselingsziekte heeft.
Voorheen waren erfelijke stofwisselingsziekten bij uitstek het terrein van de kinderarts en dit specialisme erkent dan ook het aandachtsgebied metabole ziekten. Door verbeterde zorg, uitbreiding van de diagnostische mogelijkheden en toegenomen bewustwording (‘awareness’) van erfelijke metabole aandoeningen, neemt het aantal volwassenen met een erfelijke stofwisselingsziekte sterk toe. Het zeldzame voorkomen en de specifieke problemen die zich op volwassen leeftijd voordoen maakt dat gespecialiseerde zorg voor hen belangrijk is. De zorg voor volwassenen heeft zijn eigen specifieke uitdagingen, zoals de zorg voor patiënten met een erfelijke stofwisselingsziekte tijdens de zwangerschap. Langdurig vasten, bijvoorbeeld rond een chirurgische ingreep, kan leiden tot levensbedreigende metabole ontregeling, vooral wanneer de nodige voorzorgsmaatregelen niet zijn genomen.
Het aantal patiënten met aangeboren afwijkingen van de stofwisseling dat wordt verwezen naar onze polikliniek, neemt gestaag toe. Sommige van deze patiënten worden doorverwezen door Kindergeneeskunde vanwege het feit dat ze de volwassenheid hebben bereikt, maar anderen zijn doorverwezen door hun huisarts en de regionale ziekenhuizen.
De meest voorkomende diagnoses bij de patiënten die we in onze polikliniek begeleiden, zijn: mitochondriale ademhalingsketen aandoeningen, galactosemie, vitamine B12 tekort en aanverwante stoornissen, glycogeen stapeling, fenylketonurie, en stoornissen van de vetzuurstofwisseling zoals MCADD. In het UMCG wordt nauw samengewerkt met de pediatrische afdeling ‘metabole ziekten’.
In Nederland en België wordt door de diverse (academische) afdelingen nauw samengewerkt. U vindt hierover informatie op de website www.investof.nl, die wordt bijgehouden door de collega’s van het AMC (dr. Linthorst). Nog meer informatieover stofwisselingsziekten vindt u in dit artikel in het Nederlands Tijdschrift voor Geneeskunde: https://www.ntvg.nl/artikelen/volwassenen-met-een-erfelijke-stofwisselingsziekte/icmje
En natuurlijk op goede en informatieve websites als:
mitochondriale aandoeningen: www.mitoinfo.nl
Radboud Center for Mitochondrial Medicine: www.rcmm.info